Caption: Page 48 of the 3rd edition of Isaac Newton's (1643--1727) Principia (1726). The 1st edition was Principia (1687).
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---which makes it very inaccessible today. In Newton's time, people were finally giving up on New Latin as a practical form of communication. Newton himself gave up on it and wrote his other major book Opticks (1704) in English.
Arguably the Principia is the one of the last great books written in Latin and arguably the greatest book written in Latin in terms of extractable content, NOT style.
The only later great books written in Latin yours truly can think of were those of Carl Linnaeus (1707--1778), the "father of modern taxonomy" (see Wikipedia: Carl Linnaeus bibliography).