- Say β is the mean rate at which
an infectious person infects:
e.g., 0.6 persons infected per day
which is of order the rate for
Covid-19
with NO social precautions
(see Wikipedia:
Basic reproduction number R_0;
How Long Is COVID-19 Contagious? 2020 Nov04).
- The change in
infectious population due to
new infections is
(dA/dt)_new = βA ,
where A is the current
infectious population
and we have assumed that an infected person becomes
an infectious person
with NO time delay.
Now we hypothesize the probability of continuing to be infectious
has exponential decrease
according to P=e**(-t/τ).
This formula
leads to τ being the mean length of the infectious period
(e.g., 10 days:
see
How Long Is COVID-19 Contagious? 2020 Nov04) and also leads to
(dA/dt)_ending = -A/τ
being the rate of decrease of
infectious population
due to the ending of infection.
The total change in
infectious population
then obeys the 1st order
linear differential equation
(which is what is true at every instant in time)
(dA/dt) = (dA/dt)_new + (dA/dt)_ending = (β-1/τ)A = [(βτ-1)/τ]A ,
which has the solution
(which is what is true for all time for a particular
initial condition)
A = A_0*e**[(R_0-1)/τ]t ,
where
A_0 is the infectious population
at time zero,
the e-folding time
t_e = τ/(R_0-1),
and R_0 = βτ
is the famous
basic reproduction number R_0,
the mean number of persons an
infectious person infects
during the mean infectious period.
- We see there are
3 cases:
- R_0 > 1 giving
exponential increase.
- R_0 < 1 giving
exponential decrease.
- R_0 = 1 giving
constant infectious population.
This steady-state case can hold approximately,
but holding nearly exactly must be very rare.
- Now social precautions and medical factors probably CANNOT change τ much.
However, obviously β and R_0 can be changed by social precautions.
Isolation of all
infectious persons reduces
them to zero and the
infectious population
exponential decreases
as rapidly as τ allows.
- The above analysis is very simplified, but it captures some of the main effects.
One effect it does NOT capture is that
β and R_0 effectively decrease as there are fewer people to infect.
This will happen as the
infectious population becomes
a significant part of the total population
or, if there is post-infection immunity, as
the infectious population
plus the immune population becomes
a significant part of the total population.
So there is a saturation and the infection rate slows and the
infected/immune population approaches the total population.
If a large enough part of the total popultion becomes immune
either naturally through infection or artificially through
vaccination,
then herd immunity
is achieved and β and R_0 become very small and
infectious population
exponential decreases
ideally to effectively zero
as rapidly as τ allows.
- Note that
basic reproduction number R_0
for the original
Covid-19
with no social precautions is estimated to be in the range 3.3--5.7 which
is pretty high
(see Wikipedia:
Basic reproduction number R_0).
Say we take R = 6 as a round number and 10 days for the
infectious period
(see
How Long Is COVID-19 Contagious? 2020 Nov04).
That gives β = 6/10 = 0.6 persons infected per day and
e-folding time
t_e = τ/(R_0-1) = 2 days.
So in 1 e-folding time = 2 days, the
infectious population
increases by a factor of
e = 2.71828 18284 59045 23536 ...
and in
5 e-folding times = 10 days,
the infectious population
increases by a factor of 5e ≅ 150
(CAC-32).
If A_0 = 10,000, by day 10 there are 1.5*10**6
people infected and by day 20 there are 2.25*10**8 = 225 million people
infected---exponential growth.
Of course, saturation is likely to start before 225 million people
are infected in a
country with the population size
of the
United States
(2020
population
estimate 329,484,123:
see Wikipedia:
Demographics of the United States).
- For more information on the mathematical modeling of
infectious disease, see
Wikipedia:
Mathematical modelling of infectious disease.
- Since
epidemics
and
pandemics naturally
tend to increase/decrease
exponentially, the
natural and most useful way to display their time dependent behavior is
on a semi-log plot
where the y-axis
is logarithmic
infection rate
and the x-axis
is time.
On such semi-log plots
exponential increase/decrease
regions are regions of straight lines
with positive/negative
slope.
You are losing/winning if the slope
is positive/negative.
Alas, it's almost impossible to find
websites
with semi-log plots
of infection rate.
The common assumption seems that the general public
CANNOT understand
semi-log plots---even though
a one-sentence description suffices for anyone to understand them.
- Image 2 Caption:
Fortunately, Our World in Data has
semi-log plots.
For the Covid-19 pandemic, see
Our World in Data: Coronavirus (COVID-19) Cases
(via the displayed placeholder image
alien_click_to_see_image.html)
and click on the log option
if the good folks at
Our World in Data ever restore
the log option.