Caption: An animation of the apsidal precession of an elliptical orbit of a relatively low mass astro-body about a much more massive astro-body that is effectively at rest at the center of mass of the orbital system.
Features:
Usually, the largest is cause is gravitational perturbations from other astro-bodies in the orbital system that are NOT part of the two-body system.
Another kind of gravitational perturbation is due to general relativity (GR). GR dictates a force in addition to Newtonian gravitation (which is a 1/r**2 force or inverse-square law force). The additional force varies as 1/r**4 and leads to an apsidal precession (see Wikipedia: Two-body problem in general relativity: Effective radial potential energy).
In the Solar System, this additional GR force is overwhelmingly largest for orbit of Mercury (see Wikipedia: perihelion shift of Mercury).